The VA augmentation and switching treatments for improving depression outcomes (VAST-D) study: Rationale and design considerations.
نویسندگان
چکیده
Because two-thirds of patients with Major Depressive Disorder do not achieve remission with their first antidepressant, we designed a trial of three "next-step" strategies: switching to another antidepressant (bupropion-SR) or augmenting the current antidepressant with either another antidepressant (bupropion-SR) or with an atypical antipsychotic (aripiprazole). The study will compare 12-week remission rates and, among those who have at least a partial response, relapse rates for up to 6 months of additional treatment. We review seven key efficacy/effectiveness design decisions in this mixed "efficacy-effectiveness" trial.
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عنوان ژورنال:
- Psychiatry research
دوره 229 3 شماره
صفحات -
تاریخ انتشار 2015